“Hard riding can definitely raise one’s heart rate to the same level as that in any hard fitness session. This happens for two reasons, the first being the physical effort a rider is required to expend when riding these bikes. The second is due to adrenaline, which is the most powerful heart stimulation anyone can get,” adds Alfredo Dente, official team physiotherapist at Ducati’s Super Aguri F1 MotoGP team. “But this is a situation which should not happen while cruising around on our public roads, since it would mean that speed limits and safety would definitely not be respected.”
To paraphrase Virginia Woolf: “Behind every great champion, there is always a great physiotherapist”. An aphorism that champion of two wheels as Casey Stoner, Nicky Hayden and Valentino Rossi are ready to sign after having met Alfredo Dente. The experience and the competence of this physiotherapist from Forli, professionally grew up in England and Australia, has in fact incurred them during several MotoGP championships, helping them to deal – and overcome – complex issues. No wonder the Tavullia centaur, in force to Yamaha, has chosen him also for the 2014-15 season, although Mr. Dente is officially the Team Coordinator of the SKY Racing Team VR46.
A clear demonstration of full confidence that the physiotherapist, in the past for long time operating at Ducati, has paid off. To «give me a good hand» in coping with the problems that the riders face up before and after each competition and «to allow them to get back on track quickly», Mr. Dente has focused on MLS®, laser therapy made in ASAlaser, company for over 30 years at the forefront in the study and development of therapeutic solutions.
Q. Inevitable ask you if in case of necessity you will use ASAlaser therapy also on Valentino Rossi …
A. Definitely: if there are the conditions to recourse to ASAlaser therapeutic solution, that I have chosen as travelling partner in this World Cup, I will use it even on Valentino who, as all multi-titled professionals, has as priority to be in the best condition for run.
Q. Being at the side of riders involved in MotoGP circuit is not a news for ASAlaser. One of its flagship therapies – Hilterapia® – since eight seasons support Clinica Mobile’s staff composed of doctors and physiotherapists.
A. Exactly in Clinica Mobile, where during the last few years I landed for personal needs and to solve the problems of some athletes, I have known the HILT® pulse. Comparing with the colleagues of Dr. Claudio Costa “Travelling Hospital”, currently managed by Dr. Michele Zasa, I have collected information about the validity and the effectiveness of ASAlaser therapies. The successfully cases have definitively convinced me to ask for more details.
Q. From Hilterapia® to MLS® is a short step.
A. Especially when I have found out that MLS® has given good results in treating Marc Marquez pathology.
Q. Do the news travel so fast?
A. Paolo Castelli, physiotherapist who follows Marc Marquez during this World Cup, has confirmed me the effectiveness of MLS® Laser Therapy helping the reigning World Champion to recover the best physical condition after the injury to his right ankle. A further guarantee …
Q. Beside the manual therapy, in which you are specialized, you will combine the laser therapy, after an ad hoc training in the Company ..
A. In England, where I have trained after finishing my studies in Italy, and in Australia, where I have followed a Master, I have mainly studied the manual therapy with focus on musculoskeletal diseases. Landing in the sports world, where everything travels around the need to speed up the results, I have considered, however, essential to integrate the opportunities offered by my specialization with the advantages of instrumental therapies. Laser therapy is therefore already part of my knowledge: I am now interested in exploring the benefits of MLS® in order to use it best to meet the athletes needs.
Q. What does a rider look for when he calls on you?
A. Return to be competitive in a short time is the priority of every rider when he is not in full form. Since their goal is to win, what really matters is finding the best solution to solve the problem that plagues them.
Q. A considerable responsibility for those who, like you, is called upon to provide this solution..
A. With regard to the purely “technical” aspects I don’t do any difference in treating a super champion as a Sunday athlete. What makes the real difference is the confidence to have short time: for this reason the team play that involves a variety of professionals becomes basic. The secret is to diagnose with fairness the disease and then evaluate in collaboration with other specialists the most appropriate treatment to resolve it.
Q. Always with the tight time …
A. I got used to it when I have decided to work in the world of motorcycling. When, for example, Valentino or Andrea (Iannone, ed) after a workout have pain to an arm or a calf we must be immediately ready to intervene to resolve it. For this reason I believe MLS® will help me ..
Q. What are the problems that you commonly face?
A. Riders, for their “work”, assume a particular posture that has an impact on their back and legs. I am referring specifically lumbar soreness, leg fatigue, tension in the neck and thoracic spine. Our task is to help them to overcome these issues to get on track in the best way.
Q. Your career has begun in hospitals, would you have thought to move from the ward to the circuits?
A. My professional life has been marked by a continuous ringed of opportunities: very often I was in the right place at the right time. I’ve only caught the opportunities, opening some doors …
Modesty is part of Alfredo Dente’s nature but his curriculum includes not only many years of experience in MotoGP (junior team Honda, Ducati), but also in Formula 1 (Team Minardi – current Toro Rosso). «I am aware – he concludes – that if I had not been very helpful, and above all, professional these doors would close after just one season».
Abstract: Thoracic Outlet Syndrome (TOS), especially “non-specific neurogenic” TOS, is a challenging subject for discussion because of its anatomical and pathological implications.
While the vascular type of thoracic outlet compression is recognized and accepted because of the objective findings during physical examination, supported by technologically advanced invasive and non-invasive forms of investigation, some authors, on the other hand, go as far as rejecting the existence of a non-specific neurogenic TOS since objective evidence is just not available.
A differential diagnosis can be an ambitious goal, since a whole range of conditions can cause similar symptomatology and lack of reliable clinical and diagnostic tests can compromise the effectiveness of both conservative and surgical treatment protocols. Nevertheless, surgical intervention is well accepted by both the surgeons and patients, though evidence of positive outcome is still disputed by some authors and, furthermore, in presence of an uncertain diagnosis.
It is therefore understandable the refusal of some clinicians to classify this clinical presentation as non-specific neurogenic TOS until we are certain of the causes and the mechanisms behind this pathology.
This is why assessment skills, recognition and logical interpretation of correlating subjective and objective findings may lead the clinician more effectively towards an appropriate management while more research is carried out.
Thoracic Outlet Syndrome is the most commonly used term to describe a combination of signs and symptoms related to compression of neural and vascular structures in the region correctly termed thoracic inlet (Novak CB 1996).
Various names have been attributed to the disorder over the years and these include Cervical rib syndrome, Scalenus Anticus Syndrome, Costoclavicular Syndrome, Brachiocephalic Syndrome and many others (Ault J 1998) also related to the anatomical structures which are believed to be involved with the pathological mechanisms likely to occur.
Of all cases of TOS only 10% are thought to be of vascular origin (Atasoy E 1996, Ault J 1998) and the remaining 90 % are classified as true neurogenic and non-specific neurogenic type (85%).
Historically the syndrome is associated with the presence of anomalous anatomical structures such as a cervical rib, or acquired changes in the surrounding tissues (Atasoy E 1996) a theory, accepted by many but now disputed by some, that explains the development of more or less complicated surgical approaches.
It appears, in fact, that surgery is at times proposed as an option on the basis of one diagnostic tests (electrophysiological or nerve conduction velocity test) which reliability is questionable (Ault J 1998, Gillard J 2001, Le Forestiere N 1998) with long term outcomes not very encouraging (Axelrod DA 2001, Franklin GM 2000, Landry GJ 2001).
It is evident that lack of a logical and evidence based approach in the treatment and management of this pain syndrome is a reason for concern but the debate is open and the contribution of every party involved is a step forward in the understanding and in a clearer classification.
In the US the incidence of TOS is 3-80 cases per 1000 people and it is more common in females than in males. Symptoms appear in patients aged 20-50 years. The mean age of patients who have arterial complications is 10 year older than the mean age of patients who have neurologic or venous symptoms (Kalra 2002).
The causes of TOS can be divided in osseous and soft tissue types(Ault J 1998). The osseous group comprises 30% of all TOS cases and include:
• Prominent transverse process of C7 vertebra
• Cervical rib
• First rib abnormalities
• Fracture of the first rib
• Fractured clavicle
In the soft tissue group congenital bands and ligaments variations, as well as congenital or acquired scalene muscle changes, are included (Atasoy E 1996).
It is postulated that congenital anatomical variations do not always cause the symptoms. In fact, congenital bands are present in more than half the population and less than 1% of the population ever develops TOS (Ault J 1998).
Also only 4% to 10% of patients operated on with a diagnosis of TOS present with thoracic bony anomalies such as cervical ribs (Oates SD 1996).
A recently published paper on surgery as management of patients with neurogenic TOS, concluded that the presence or absence of a cervical or anomalous first rib did not improve the success rate (Sanders RJ 2002) and that neck trauma is the most common cause for the condition in the presence of abnormal ribs.
Cervical and anomalous first rib would therefore more likely to be the predisposing factor rather than the cause for TOS (Roos DB 1999, Sanders RJ 2002).
Anatomy & Pathology
Several musculoskeletal structures contribute to form the area anatomically termed the thoracic inlet (fig.1).
Many sites of compression have been identified but the most common are believed to involve the interscalene muscles interval, the costoclavicular space and the subcoracoid area.
The brachial plexus and both the subclavian artery and vein, supplying the upper limb, are surrounded by both bony and soft tissue structures in a narrow anatomic space.
The first rib is broad, flat, wider and shorter than succeeding ribs. It slopes downward and forward from its vertebral to its sternal head. The neurovascular structures pass above its most inferior part. The central portion superiorly presents two grooves, the posterior one for the subclavian artery and the anterior one for the subclavian vein. Between the grooves is a tubercle for the attachment of the scalenus anterior muscle.
The clavicles has two curves, convex forward medially and convex posteriorly on its lateral aspect. Medially it is in relation inferiorly and posteriorly with the subclavian vessels and with the cords and terminal branches of the brachial plexus, being separated from them by the subclavius muscle (Kreig L 1993).
Two mechanisms of entrapment can occur in this area:
1) Compression against the medial aspect of the rib
2) Traction on the ascending neurovascular structures over the first rib.
Space occupying lesion of the thyroid gland, pleura or lung could also cause compression against the first rib.
A chronically elevated first rib in emphysematous patients, for example, can provoke stretch on the neurovascular elements ascending higher to pass over the rib. Its increased obliquity, by decreasing the costoscalene angle, may also make these structures more vulnerable to compression by scalene anterior muscle.
Other causes may be identified in a postfixed brachial plexus arising from C6-T2 having to ascend higher to exit the thorax.
Postural changes, affecting mainly women with excessively long necks and low set shoulders (Kreig L 1993) is considered to be one of the causes also.
The scalenus anterior inserts on the anterior tubercle of the third and sixth cervical vertebrae. Its fibers run inferiorly, anteriorly and laterally to insert on the scalene tubercle of the first rib
The scalenus medius vertebral insertion is on the posterior tubercle of the transverse process usually from the first cervical certebrae to the seventh and the distal insertion is on the superior aspect of the first rib. These muscles usually lie in contact with each other and the roots of the brachial plexus emerge from the cleft between the two, with the subclavian artery joining the laterally. The subclavian vein generally passes anterior to the scalenus amterior (Nichols HM 86).
Pectoralis minor arises from the outer surface of the second to fifth ribs and inserts onto the coracoids process after running upwards and laterally.
The cords of the brachial plexus pass inferior to the coracoid and posterior to the muscle before entering the axilla.
Variations of the scalenus anterior attachment, like a more posterior insertion, widened or conjoined insertion of scalenus anterior or medius may narrow the costoscalene triangle.
A spasm or hypertrophy of these muscles, from trauma (whiplash injury), poor posture or nerve root irritation could potentially cause TOS symptoms.
The ventral roots of the primary divisions of the 5th, 6th, 7th, 8th cervical and 1st thoracic spinal nerves make up the brachial plexus, occasionally with twigs from the 4th cervical and 2nd thoracic nerves. (Nichols HM 86).
The roots unite to form three trunks after emerging from the slit between the anterior and middle scalene muscles.
The 5th and 6th nerves form the upper trunk, the C7 ramus forms the middle trunk and the C8 and the 1st thoracic nerves form the lower trunk. The latter lies in close relation to the first rib.
The trunks then rearrange to form three cords behind the clavicle: lateral, posterior, and medial before passing beneath the pectoralis minor together with artery and vein and entering the axilla where the plexus divides into median, ulnar, radial and musculocutaneous nerves.
“Sites of potential nerve constriction (e.g. the carpal tunnel syndrome) or transit points of small branches across fascial planes are locations of special risk. Conditions here a ripe both for the production of ectopic neural pacemaker nodules upon local trauma, and also for their mechanical stimulation during body movement.”(Devor M 1991): the quotation refers to a new concept and interpretation of neurogenic pain.
An insult in the peripheral nervous system can progress, for some reason, to abnormal discharge and produce a response modulated and modified by the central nervous system.
I like to think that there could be a close relation between the concept of ectopic neural pacemaker (Elvey and O’Sullivan 2002) and non-specific TOS clinical presentation.
Diagnosing skills have become a priority and a necessity for those involved in treating patients with musculoskeletal disorders, especially when treatment is expected after a physical evaluation which represents the first contact with the clinician.
There are numerous conditions that can suggest or even mimic neurogenic TOS and they need to be considered carefully and ruled out during the subjective and objective examination.
Some systemic diseases like RA, angina, Pancoast tumor, hypothyroidism, spinal cord lesion for example or glenohumeral instability, impingement syndrome affecting the shouldergirdle, cervical degenerative disc disease, cervical radiculopathy, myofascial system referred pain (scalenes muscles, pectoralis muscles supraspinatus muscles) peripheral nerves entrapment like Carpal tunnel syndrome (CTS) to mention the most common, they potentially can be all misinterpreted as TOS.
Clinical tests in use and largely described comprise:
• The Wright’s test or Hyperabduction Manoeuvre (Magee DJ 1997) used to detect compression in the costoclacvicular space: the patient’s arm is hyperabducted with the hand over the head with the elbow and the arm in the coronal plane both in sitting and supine positions. Taking a breath, rotating or extending the neck might have an additional effect. The pulse is palpated for differences.
• The Adson Manouevre used to detect the scalenus anterior entrapment: the examiner locates the radial pulse then the patient’s head is rotated towards the tested shoulder. Neck extension, lateral rotation and extension of the shoulder while the patients is instructed to breath in deeply should provoke radial pulse disappearance.
• Roos Test or elevated arm stress test (EAST) applied to detect vascular insufficiency and the Provocative elevation test as a variation: patient standing, abducts the arms to 90 degrees, laterally rotates the shoulders and flexes the elbows to 90 degrees. The patient is then asked to open and close his hands slowly for three minutes. If ischemic pain, heaviness or profound weakness of the arms, tingling in the hand or inability to keep the arm in the starting position are detected then the test is considered positive.
• The Allen test, again, looks for variations in the pulse (disappearance) examined while the patient’s elbow is held flexed to 90 degrees, the shoulder is held extended horizontally and laterally rotated and the head is actively rotated away from the test side.
Obliteration of pulses in at least 92.6% of asymptomatic adults was described using the Wright’s test or hyperabduction manouever (Oates SD 1996).
Positive Roos (EAST) test was found to be positive in 74% of asymptomatic controls and 92% of carpal tunnel syndrome patients (Oates SD 1996) and Wilbourne wonders how the same test can actually be used to diagnose any brachial pathology since he believes that no mechanical stress can be achieved anatomically in the position required by the test (Wilbourn ASA J 1999).
On the other hand the Adson test was found to be the most effective when used in combination with another test, especially the Roos (EAST) test (Gillard J 2001).
Many are unfortunately disputing the validity and reliability of the above tests, to diagnose TOS.
In terms of reliability and accuracy, with reference to neurogenic TOS, subjective diagnostic tests alone also do not represent a safe tool we can solely rely on.
X-ray of the cervical and thoracic spine clearly is the first choice to confirm some anatomical abnormalities of the skeletal system and plain chest x-ray can be helpful to either investigate further or rule out the presence of malignant growth. Ault et al. (1998) make clear that nerve conduction velocity (NCV) tests are not reliable when dealing with non-specific TOS because no normal value really exists to be compared with and that range can vary with arm positions as well as right to left. Gillard et al (2001) dispute the use of electrophysiological studies because the access to the thoracic inlet is very difficult and therefore contributing to a high rate of normal readings. This appears to be the reason that has fuelled the controversy about the existence of pure neurological forms of TOS. Moreover, because the nerve entrapment can be intermittent and can involve an extremely short segment of the nerve, therefore readings, again, can be normal.
Roos (1999) agrees with the above theory also shared, in his opinion, with many neurologists and furthermore, becasue the “C” fibers, which are thought to be involved possibly from compression ischemia, cannot be studied with current technology then, obviously, the results cannot be considered highly significant.
On the other hand, although controversy over the use of NCV test is well acknowledged, Le Forestier et al. (1998) believe that electrophysiological studies are an important aid to localize the site of the lesion in case of true neurogenic TOS and they report a connection between NCV tests and radiological tests showing congenital bilateral cervical rib or an elongated C7 transverse process in 6 cases of female patients. Surgery also confirmed the presence of a fibrous band causing the lower part of the brachial plexus to be over stretched and angulated. Surgery relieved pain after 1-4 weeks but at 1 year follow-up the electrophysiological results were unchanged (Le Forestiere N 1998).
Other diagnostic tests include Doppler ultrasonography, which was found useful in providing evidence of vascular compression only in patients with at least two positive provocative tests but not in asymptomatic subjects (Gillard J 2001).
In the same study Gillard et al. considered the use of Helical 3D CT angiography and they found it helpful to locate the site of vascular compression. It was found, interestingly, that some patients showed evidence of stenosis beneath the pectoralis minor muscle, which might explain why some patients remain symptomatic after surgery limited to the first rib. They concluded that the use of this diagnostic tool may be appropriate to select the best surgical approach but there would still be the need to choose which vascular component to investigate, either arterial or venous, since both are not necessarily affected at the same time.
Both the above diagnostic tests would not be useful in the diagnosis of neurogenic TOS as they specifically investigate the vascular system.
Thus, it is not surprising that without any objective evidence there is some scepticism about the existence of such syndrome after all, however TOS can be generally classified in four categories:
• True Neurogenic
• Non-specific Neurogenic
It is believed that about 10% of all TOS cases are predominantly vascular (venous and arterial) while the remaining cases are neurogenic (true or non-specific or disputed neurogenic) (Atasoy E 1996).
Roos (1999) describes the latter presenting with progressing symptoms ranging from light, occasional nocturnal or positional paresthesias in the arm and hand, to incapacitating pain and disuse with weakness and even atrophy of the intrinsic muscle of the hand with diminished sensation in the ulnar nerve distribution.
Wilbourn (1999) too believes that a progression of the symptoms characterizes the non-specific or disputed neurogenic TOS although the mechanisms and manifestations of this progression remain unclear.
Atasoy (1996) describes a combination of symptoms presentations according to which part of the brachial plexus is believed to be involved in the pathological process. In his opinion the most common of all (90%-95%) involves the C8-T1 nerve roots and their distribution with paraesthesie involving the ulnar nerve, weakness, easily fatigued extremity, coolness, cold intolerance and swelling. The pain is usually dull, aching and at times sharp and throbbing. The involvement of the sympathetic system and the accompanying, sometimes, clinical features (vasomotor changes like coldness and blanching of the hand, shiny skin, thickening and curling of the fingernails) is believed due to the common path shared by the sympathetic fibers with the fibers carrying deep pain sensation passing through sympathetic ganglions and entering the anterior surface of C8-T1.
Upper plexus involvement (C5, C6, C7) can cause pain on the side of the neck radiating to the mandible and the face with sometimes earache and occipital headaches, always according to Atasoy (1996). This theory is highly criticized by Wilbourn (1999) who points out that the above anatomical regions are not innervated by the brachial plexus.
It’s more likely that the greater occipital nerve, believed to be responsible for the mediation of occipital pain, may be secondarily in spasm as it passes the posterior musculature of the neck.
Often, however, we meet patients who, whether symptoms in the upper extremity may or may be not caused by compression at the thoracic outlet, present commonly with very specific findings well described by Ault et al. (1998):
• Usually female patients in their late teens to fourth decade;
• De-conditioned with jobs involving static use of Upper Limbs and repetitive use of the hands;
• Symptoms aggravated by sleeping on affected side with arm overhead, overhead use of arm, carrying heavy objects in hand or over shoulder, repetitive use of arms and turning and tilting head to opposite side;
• Symptoms eased by arm adducted and flexed across the body, hand tucked in pocket or use of sling;
• Pain behavior during the 24 hours showing sleeping disturbance and worsening of symptoms after use (latency);
• History of insidious onset with nocturnal symptoms noted at first with negative diagnostic tests and possible trauma in distant past related to first rib or clavicle.
We can safely acknowledge that reaching a plausible diagnosis of non-specific or disputed neurogenic TOS is not a simple task especially considering that such a syndrome is not yet fully recognized by many in the medical profession.
Treatment, therefore, can vary according to the clinical presentation, to the time in which such presentation occurs and to the severity.
A thorough subjective examination can provide a vital and invaluable collection of information, with particular attention to the body chart. Pain behavior and its changes in relation to occupation and other activities involving the use of the upper limbs becomes an essential clue.
The objective examination should be carried out with the aim to locate the site of possible pathology and rule out mimicking conditions, especially if malignant causes are suspected.
Also Observation for postural disorders, muscle length tests, motion palpation test and neural tissue provocation tests, as well as the clinical provocative tests mentioned earlier, are a combination of valuable tools at the clinician’s disposal which reliability can be justified if they are all applied in combination and systematically according to principles of accepted anatomy and biomechanics.
All findings, in fact, are supposed to correlate with each other including any available objective diagnostic investigations in order to implement a plan of treatment (Elvey RL 2002).
Great concern, nonetheless, is represented by the use of invasive and costly procedures when evidence of their efficacy appears to be unsupported, with lack of randomized controlled trials.
Many procedures are described in the available literature:
1) Cervical rib resection
4) First rib resection
5) Excision of anomalous fibrous bands
7) Combinations of the above.
The anatomic approaches vary and they include supraclavicular, transclavicular, subclavicular, transaxillary, posterior, and combined.
Transaxillary first rib resection and cervical scalenectomy are considered the most popular and standard procedures (Atasoy E 1996).
The former is mainly recommended for the lower type of TOS involving C8-T1 roots of the brachial plexus while the latter is preferred for the upper type of TOS with C5-C6-C7 root symptoms.
A combination of the two procedures above is also believed to be very effective in physically suitable patients in order to achieve a total decompression of the region and to reduce chance of recurrence with a 75% to 80% of improvement in the extremities.
In a recent study Franklin et al. (2000) examined insured workers under a compensation system in the Washington state. Two sample groups were identified, the first one between 1986 and 1991 received surgical treatment, and the second between 1987 and 1989 did not.
The patients in the surgical group had 50% higher medical costs and were three to four times more likely to be work disabled.
The non-specific Neurogenic TOS diagnosis and the complexity of workers compensation cases were identified as possible causes for worse outcomes and a need for well-designed and randomized trials was emphasized.
Axelrod et al (2001) study looked at operative decompression of the brachial plexus via supraclavicular approach in 170 patients diagnosed with of neurogenic TOS between 1990 and 1999.
After an average follow-up of 47 months 65% improved symptoms were reported with 64% of patients claiming satisfaction with the operative outcome while 35% of patients remained on medication and 18% were disabled.
Operative decompression was considered beneficial for most patients but it was postulated that socioeconomic status might be related to poor outcome after surgery and psychological factor, education and marital status were found to be associated with self-reported disabilities and, therefore, should be studied prospectively.
Landry et al (2001) selected 79 patients with disputed neurogenic TOS between 1990 and 1998 and they reevaluated them at a mean follow-up of 4.2 years after the initial evaluation. Fifteen patients (19%) underwent first rib resection surgery performed by others, whereas 64 (81%) had conservative treatment. The authors did not take part in the decision-making process with reference to the management of the patient’s sample.
There was no significant difference between the two groups with most patients able to return to work and demonstrated improvement of symptoms at long-term follow-up. Patients who underwent surgery though missed more work than the conservatively treated patients and first rib resection did not improve functional outcome.
Interestingly, Lindgren (1997) examined conservative treatment in 119 patients with symptoms of arm pain and possible TOS after a mean follow-up of 24.6 months.
The intervention consisted on restoration of normal function of they cervical and thoracic spine by means of home exercises.
At follow up 88% of the patients were satisfied with the outcome of their treatment. Seventy-three percent of the patients returned to work after the therapy although return to work was more often successful if sedentary rather then heavy.
It’s very unclear if non-specific neurogenic TOS can be considered a diagnosis and it is fair to dispute its existence since a lot of findings that characterize this pain syndrome cannot be clearly explained on the basis of the current anatomical and pathological knowledge.
It is obvious that more studies and research are vital to establish the real cause for this syndrome and the validity of both conservative and surgical treatment, bearing in mind that surgery does not seem to be cost effective and it includes risks that deserve careful consideration.
In the meantime a thorough and comprehensive examination is the most recommended approach, in order to facilitate a differential diagnosis at early stages in the best interest of both the patient and the clinician.
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